| Title | |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Goyal P, Kim J, Feher A, Ma CL, Gurevich S, Veal DR, Szulc M, Wong FJ, Ratcliffe MB, Levine RA, Devereux RB, Weinsaft JW |
| Journal | Coron Artery Dis |
| Volume | 26 |
| Issue | 8 |
| Pagination | 642-50 |
| Date Published | 2015 Dec |
| ISSN | 1473-5830 |
| Keywords | Aged, Aged, 80 and over, Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography, Echocardiography, Exercise Test, Female, Heart, Humans, Logistic Models, Male, Middle Aged, Mitral Valve Insufficiency, Multivariate Analysis, Myocardial Infarction, Myocardial Perfusion Imaging, Percutaneous Coronary Intervention, Risk Assessment, Stroke Volume |
| Abstract | OBJECTIVE: Ischemic mitral regurgitation (MR) is common, but its response to percutaneous coronary intervention (PCI) is poorly understood. This study tested the utility of myocardial perfusion imaging (MPI) for the stratification of MR response to PCI. METHODS: MPI and transthoracic echocardiography (echo) were performed among patients undergoing PCI. MPI was used to assess stress/rest myocardial perfusion. MR was assessed via echo (performed before and after PCI). RESULTS: A total of 317 patients with abnormal myocardial perfusion on MPI underwent echo 25±39 days before PCI. MR was present in 52%, among whom 24% had advanced (≥moderate) MR. MR was found to be associated with left ventricular (LV) chamber dilation on MPI and echo (both P CONCLUSION: The extent and distribution of single-photon emission computed tomography-evidenced myocardial perfusion defects impact MR response to revascularization. An increased magnitude of inferior fixed perfusion defects predicts post-PCI progression of MR. |
| DOI | 10.1097/MCA.0000000000000271 |
| Alternate Journal | Coron. Artery Dis. |
| PubMed ID | 26049923 |
| PubMed Central ID | PMC4631658 |
| Grant List | K23 HL102249 / HL / NHLBI NIH HHS / United States R01 HL109506 / HL / NHLBI NIH HHS / United States K23 HL102249-01 / HL / NHLBI NIH HHS / United States |