| Title | |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Kim J, Medicherla CB, Ma CL, Feher A, Kukar N, Geevarghese A, Goyal P, Horn E, Devereux RB, Weinsaft JW |
| Journal | PLoS One |
| Volume | 11 |
| Issue | 1 |
| Pagination | e0147349 |
| Date Published | 2016 |
| ISSN | 1932-6203 |
| Keywords | Blood Pressure, Echocardiography, Endomyocardial Fibrosis, Female, Heart Ventricles, Humans, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Stroke Volume, Ventricular Dysfunction, Right, Ventricular Function, Right, Ventricular Pressure, Ventricular Remodeling, Ventricular Septum |
| Abstract | BACKGROUND: Non-ischemic fibrosis (NIF) on cardiac magnetic resonance (CMR) has been linked to poor prognosis, but its association with adverse right ventricular (RV) remodeling is unknown. This study examined a broad cohort of patients with RV dysfunction, so as to identify relationships between NIF and RV remodeling indices, including RV pressure load, volume and wall stress. METHODS AND RESULTS: The population comprised patients with RV dysfunction (EF 6-fold more common in the highest, vs. the lowest, common tertile of PASP and RV size (p CONCLUSION: Among wall stress components, NIF was independently associated with RV chamber dilation and afterload, supporting the concept that NIF is linked to adverse RV chamber remodeling. |
| DOI | 10.1371/journal.pone.0147349 |
| Alternate Journal | PLoS ONE |
| PubMed ID | 26799498 |
| PubMed Central ID | PMC4723145 |
| Grant List | P30 CA008748 / CA / NCI NIH HHS / United States K23 HL102249-01 / HL / NHLBI NIH HHS / United States |