| Title | |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Chinitz JS, Chen D, Goyal P, Wilson S, Islam F, Nguyen T, Wang Y, Hurtado-Rua S, Simprini L, Cham M, Levine RA, Devereux RB, Weinsaft JW |
| Journal | JACC Cardiovasc Imaging |
| Volume | 6 |
| Issue | 2 |
| Pagination | 220-34 |
| Date Published | 2013 Feb |
| ISSN | 1876-7591 |
| Keywords | Adult, Aged, Anterior Wall Myocardial Infarction, Chi-Square Distribution, Contrast Media, Echocardiography, Doppler, Color, Echocardiography, Doppler, Pulsed, Female, Humans, Inferior Wall Myocardial Infarction, Logistic Models, Magnetic Resonance Imaging, Cine, Male, Middle Aged, Mitral Valve, Mitral Valve Insufficiency, Multivariate Analysis, Myocardium, Odds Ratio, Papillary Muscles, Predictive Value of Tests, Prospective Studies, Registries, Risk Assessment, Risk Factors, Time Factors |
| Abstract | OBJECTIVES: This study sought to assess patterns and functional consequences of mitral apparatus infarction after acute myocardial infarction (AMI). BACKGROUND: The mitral apparatus contains 2 myocardial components: papillary muscles and the adjacent left ventricular (LV) wall. Delayed-enhancement cardiac magnetic resonance (DE-CMR) enables in vivo study of inter-relationships and potential contributions of LV wall and papillary muscle infarction (PMI) to mitral regurgitation (MR). METHODS: Multimodality imaging was performed: CMR was used to assess mitral geometry and infarct pattern, including 3D DE-CMR for PMI. Echocardiography was used to measure MR. Imaging occurred 27 ± 8 days after AMI (CMR, echocardiography within 1 day). RESULTS: A total of 153 patients with first AMI were studied; PMI was present in 30% (n = 46 [72% posteromedial, 39% anterolateral]). When stratified by angiographic culprit vessel, PMI occurred in 65% of patients with left circumflex, 48% with right coronary, and only 14% of patients with left anterior descending infarctions (p CONCLUSIONS: Papillary muscle infarction is common after AMI, affecting nearly one-third of patients. Extent of PMI parallels adjacent LV wall injury, with lateral infarction-rather than PMI-associated with increased severity of post-AMI MR. |
| DOI | 10.1016/j.jcmg.2012.08.016 |
| Alternate Journal | JACC Cardiovasc Imaging |
| PubMed ID | 23489536 |
| PubMed Central ID | PMC4048744 |
| Grant List | K23 HL102249-01 / HL / NHLBI NIH HHS / United States K24 HL067434 / HL / NHLBI NIH HHS / United States R01 HL109506 / HL / NHLBI NIH HHS / United States K23 HL102249 / HL / NHLBI NIH HHS / United States R01 HL072265 / HL / NHLBI NIH HHS / United States |