| Title | |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Capone G, Goyal P, Ares W, Lannigan E |
| Journal | Am J Med Genet C Semin Med Genet |
| Volume | 142C |
| Issue | 3 |
| Pagination | 158-72 |
| Date Published | 2006 Aug 15 |
| ISSN | 1552-4868 |
| Keywords | Adolescent, Adolescent Behavior, Adult, Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Child, Child Behavior Disorders, Depression, Down Syndrome, Humans, Intellectual Disability, Mood Disorders, Obsessive-Compulsive Disorder, Psychotic Disorders, Stereotypic Movement Disorder |
| Abstract | The term dual-diagnosis refers to a person with mental retardation and a psychiatric disorder. Most children with Down syndrome (DS) do not have a psychiatric or neurobehavioral disorder. Current prevalence estimates of neurobehavioral and psychiatric co-morbidity in children with DS range from 18% to 38%. We have found it useful to distinguish conditions with a pre-pubertal onset from those presenting in the post-pubertal period, as these are biologically distinct periods each with a unique vulnerability to specific psychiatric disorders. Due to the increased recognition that psychiatric symptoms may co-occur with mental retardation, and are not inextricably linked to cognitive impairment, these conditions are considered treatable, in part, under a medical model. Improvement in physiologic regulation, emotional stability, and neurocognitive processing is one of the most elusive but fundamental goals of pharmacologic intervention in these disorders. |
| DOI | 10.1002/ajmg.c.30097 |
| Alternate Journal | Am J Med Genet C Semin Med Genet |
| PubMed ID | 16838318 |